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Objective: To synthesise and critically appraise evidence on how plant ncRNAs microRNAs (miRNAs), small interfering RNAs (siRNAs), long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) regulate secondary metabolism in medicinal plants, and to map translational opportunities and unresolved gaps

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Symptom-based adjustment may also fail to detect silent risks such as endocrine disruption, glucose dysregulation, inflammatory responses, contamination-related effects, or organ-specific adverse events